Farmakologija i toksikološki profil novosintetisanih derivata hromana-2,4-diona u funkciji antikoagulativne aktivnosti in vivo Stanković, Nevena, 1987- Priloženi rukopis sumira sintezu šest novih derivata 3-(1-aminoetiliden) hroman-2,4-diona, označenih kao 2a-f, i dva nova derivata 4-hidroksi-3-(1-imino-etil)-2H-hromen-2-ona označenih kao 2g-h, odnosno evaluaciju njihove in vivo anti- koagulativne aktivnosti nakon intraperitonealne i oralne aplikacije na odraslim pacovima Wistar soja, sa ciljem procene njihovog kliničkog antikoagulativnog potencijala, farmakologije i toksičnosti. The enclosed manuscript summarizes the efforts of synthesis and evaluation of six novel 3-(1-aminoethylidene)chromane-2,4-diones, namely 2a-f, as well as of two novel 4-hydroxy-3-(1-iminoethyl)-2H-chromene-2-one derivatives, namely 2g-h, as in vivo anticoagulants by means of intraperitoneal and per os administration to adult male Wistar rats. Condensates were screened to expose their anticoagulant potential, pharmacology and toxicity. Mladenović, Milan, 1984- Kostić, Danijela A., 1969- Mihailović, Mirjana. Vuković, Nenad, 1976- Mihailović, Vladimir, 1984- Matić, Sanja, 1981- 2018 2018 2018 2018 2018 2018 2018 2018 baccalaureate Dissertation XXXIII, 384 lista 126485568 bytes o:1008 ID=1024563944 ; D-3168 thesis:6061 cobiss:1024563944 https://phaidrakg.kg.ac.rs/o:1008 Thesis:6061 Cobiss:1024563944 srp CC BY-NC-ND 2.0 AT http://creativecommons.org/licenses/by-nc-nd/2.0/at/