o:1241 Sinteza, karakterizacija i biološka aktivnost kompleksa Pd(II) sa etilendiaminskim i kumarinskim derivatima aminokiselina SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OFPd(II) COMPLEXES WITH ETHYLENDYAMINE AND COUMARINEAMINO ACIDS DERIVATIVES : doctoral dissertation sr U ovoj Doktorskoj disertaciji opisana je sinteza i karakterizacija nekoliko novih liganada, etilendiaminskih i kumarinskih derivata nekih aminokiselina i odgovarajućih paladijum(II)-kompleksa. Najpre je opisana sinteza i karakterizacija O,O'-dialkil estara (S,S)-etilen--diamin-N,N'-di-(2,2'-di-(4-hidroksi-benzil))sirćetne kiseline (H2-(S,S)-eddtyr). Ova jedinjenja su dobijena direktnom reakcijom između tetradentatnog liganda (S,S)-etilendiamin-N,N'-di-(2,2'-di-(4-hidroksi-benzil))sirćetne kiseline i odgovara- -jućeg apsolutnog alkohola (etanol, 1-propanol, 1-butanol i 1-pentanol) u molskom odnosu 1 : 2, uz uvođenje gasovitog hlorovodonika. Takođe, prikazana je i sinteza kumarinskih derivata nekih aminokiselina. Pomenuti ligandi dobijeni su refluktovanjem smeše 3-acetil-4-hidroksi kumarina, hidrohlorida metil estara aminokiselina S-valina, glicina, S-metionina ili S-triptofana i trimetilamina. Tok reakcije je praćen tankoslojnom hromatografijom (toluen : aceton = 8 : 2). Nakon završene reakcije, uparavanjem rastvarača do polovine svoje zapremine i dodavanjem 5 cm3 vode, dobijeni sukumarinski derivati sa pomenutim aminokiselinama. Strukture i sastav izolovanih liganada pretpostavljene su primenom elementalne mikroanalize, infracrvene, 1H i 13C NMR spektroskopije, a potvrđene na bazi rezultata rendgenske strukturne analize u slučaju metil 2-[(1-(2,4-dioksohroman-3-iliden)etilamino-3-metil)]butanoata. Dobijeni O,O'-dialkil estri (S,S)-etilendiamin-N,N'-di-(2,2'-di-(4-hidroksi--benzil))sirćetne kiseline su upotrebljeni za sintezu odgovarajućih paladijum(II)--kompleksa. Sastav dobijenih kvadratno-planarnih paladijuma(II)-kompleksa potvrđen je elementalnom analizom, dok je struktura izolovanih kompleksa pretpostavljena na osnovu infracrvene, 1H i 13C NMR spektroskopije. The synthesis and characterization of several new ligands, ethylenediamine and coumarin derivatives of some amino acids and corresponding palladium(II)-complexes are described in this PhD thesis. Firstly, the synthesis and characterizations of O,O'-dialkyl esters of (S,S)-ethylenediamine- -N,N'-di-(2,2'-di-(4-hydroxy-benzyl)acetic acid, H2-(S,S)-eddtyr are described. These compounds were obtained by direct reaction between tetradentate ligand (S,S)-ethylenediamine-N,N'-di-(2,2'- -di-(4-hydroxy-benzyl)acetic acid and the corresponding absolute alcohol (ethanol, 1-propanol, 1-butanol, 1-pentanol) in a molar ratio 1:2 with the addition of gaseous hydrogen-chloride. Also, the synthesis of coumarin derivatives of some amino acids are also shown. Mentioned ligands were obtained refluxing a mixture of 3-acetyl-4-hydroxy coumarin, hydrochloride methyl esters of amino acids S-valine, glycine, S-methionine or S-tryptophan and trimethylamine. The progress of the reactions was monitored by TLC (toluene : acetone = 8 : 2). After the finishing of the reactions, the evaporation of solvent to the half of native volume and addition of 5 cm3 of water, the obtained coumarin derivatives with mentioned amino acids were obtained. The obtained O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-(2,2'-di-(4-hydroxy- -benzyl)acetic acids are used for synthesis of the corresponding palladium(II)-complexes. The composition of obtained square-planar palladium(II)-complexes was confirmed by elemental microanalysis, and the structure of isolated complexes is assumed on basis of infrared, 1H and 13C NMR spectroscopy. 144 lista ID=1024656104 91552101 7323 91552100 1024656104 2020-02-28T12:20:15.053Z 45 no 46 mentor Danijela, 1986- Stojković 2018 63 mentor Verica Jevtić 2018 63 član komisije Srećko Trifunović 2018 63 član komisije Tibor Sabo 2018 63 član komisije Ratomir Jelić 2018 63 član komisije Gordana Radić 2018 63 član komisije Nenad Vuković 2018 PDF/A 6651545 http://phaidrabg.bg.ac.rs/o:1241 no yes 5 2020-02-28T12:20:15.320Z 70 R2-(S,S)-eddtyr ligandi, kumarinski derivati aminokiselina Paladijum, Kompleksna jedinjenja 1738 34A08 34A0803 2018