o:1335 Prediktivna vrednost evociranih potencijala na dugotrajni ishod multiple skleroze Predictive value of evoked potentials on the long-term outcome of multiple sclerosis : doctoral dissertation sr Uvod: Cilj je bio da ispitamo prediktivnu vrednost evociranih potencijala (EP) na dostizanje povoljnog ishoda dugogodišnjeg lečenja imunomodulatornom terapijom obolelih od relapsno-remitentne multiple skleroze (RRMS), da procenimo značaj EP kao pokazatelja kognitivnog oštećenja, i uticaj depresije i zamora na EP i ishod lečenja. Metodologija: U retro- i prospektivnom istraživanju oboleli su praćeni tokom 2, 5 ili 10 godina. Na početku praćenja su rađeni vizuelni evocirani potencijali (VEP) i kognitivni EP (ERP), takođe i nakon dugogodišnjeg praćenja. Dobijeni su podaci o optičkom neuritisu (ON), procenjeni stepen onesposobljenosti, kognitivne funkcije, stepen depresivnosti i zamora, rađena magnetna rezonanca (MR) endokranijuma. Povoljan ishod lečenja predstavlja dostizanje NEDA-3 (No Evidence of Disease Activity). Rezultati: Učestvovalo je 112 sobolelih od RRMS i 32 zdrave kontrole. NEDA-3 je dostiglo 19 (22,9%), a nije dostiglo 64 (77,1%) lečenih od RRMS. Nalaz EP skora (r=0,008, OR=0,344 (0,156–0,757)) i latence (r=0,042, OR=0,966 (0,934–0,999)) na početku bolesti su prediktivni faktori na dostizanje NEDA-3. Depresija utiče na kognitivno oštećenje (r=0,047, OR=1,077 (1,001–1,159)) i povećanje onesposobljenosti (r=0,002, OR=1,143 (1,051–1,243)). Depresija i zamor negativno utiču na kognitivne funkcije, a ne utiču na amplitude i latence ERP. Reakciono vreme pozitivno korelira sa depresijom (r=0,246, p=0,01) i zamorom (r=0,281, p=0,01). Zaključak: Uredan VEP na početku bolesti uvećava šansu za dostizanje NEDA-3 oko 6 puta. Depresija utiče na povećanje onesposobljenosti i kognitivno oštećenje. Depresija i zamor negativno utiču na kognitivne funkcije, a ne utiču na amplitudu i latencu ERP. ERP ne mogu učestvovati u proceni kognitivnog oštećenja obolelih od RRMS. Objective: The study examined predictive value of evoked potentials (EP) to achieve a outcome of long-term treatment of patients with relapsing-remitting multiple sclerosis (RRMS) with first-line immunomodulatory therapy, to assess EP as an indicator of cognitive impairment, and impact of depression and fatigue on EP and the outcome of treatment. Method: In retrospective and prospective study patients were followed for 2, 5 or 10years. At the diagnosis visual evoked potentials (VEP) and event-related potentials (ERP) were done, also after follow-up period. Each patient was assigned a degree of disability – EDSS (Expanded Disability Status Scale), cognitive functions, degree of depression and fatigue, MRI of the endocranium. Favourable outcome is achieving NEDA-3 (No Evidence of Disease Activity). Results: A total of 112 patients with RRMS and 32 healthy controls participated. NEDA-3 reached 19 (22,9%) and did not 64 (77,1%) treated patients. We found that the VEP score (р=0,008, OR=0,344 (0,156–0,757)) and latency (r=0,042, OR=0,966 (0,934–0,999)) at diagnosis were predictive factors to achieve NEDA-3. Depression affects cognitive impairment (r=0,047, OR=1,077 (1,001-1,159)) and increases future disability (r=0,002, OR=1,143 (1,051-1,243)). Depression and fatigue negatively affected cognitive functions, and did not affect the ERP. Reaction time (RT) positively correlated with depression (r=0,246, p=0,01) and fatigue (r =0,281, p=0,01). Conclusions: Normal EP findings at diagnosis are 6 times more likely to achieve NEDA. Depression affects disability and cognitive impairment. Depression and fatigue have a negative impact on cognitive functions, and have no effect on ERP. Amplitude and latency cannot participate in risk assessment for the cognitive impairment in patients with RRMS. ID=35222025 ; D=3410 91552101 8022 91552100 35222025 2021-03-29T16:17:28.053Z 45 no 46 mentor Snežana, 1985-, 61397513 Simović 2020 63 mentor Svetlana, 1965-, 6278247 Miletić Drakulić 2020 63 predsednik komisije Tihomir, 1966-, 13762919 Ilić 2020 63 član komisije Ivan, 1985-, 14277991 Srejović 2020 63 član komisije Milica, 1980-, 24912231 Borovčanin 2020 68 листова 1594516 http://phaidrabg.bg.ac.rs/o:1335 no yes 4 2021-03-29T16:17:28.320Z 70 multipla skleroza, evocirani potencijali, depresija, zamor,kognitivno oštećenje, optički neuritis, NEDA. multiple sclerosis, evoked potentials, depression, fatigue, cognitiveimpairment, optic neuritis, NEDA. 616.832-004(043.3) Multipla skleroza - Imunomodulatori - Lečenje 1738 34A05 2020