o:1537 Efekti akutnog oštećenja bubrega nefrotoksičnim agensima na funkciju miokarda pacova ǂThe ǂeffects of acute kidney injury induced by nephrotoxic agents on myocardial function in rats : doctoral dissertation sr Cilj ovog istraživanja je da ispita uticaj akutnog oštećenja bubrega izazvanog nefrotoksičnim agesima: gentamicinom, diklofenom i folnom kiselinom na funkciju miokarda i inflamacijsko-oksidacioni status pacova. Istraživanje je obuhvatilo 100 pacova Wistar albino soja muškog pola starosti 6 nedelja, prosečne telesne mase oko 200 grama. Pacovi su podeljeni u tri eksperimentalne grupe od kojih je svaka tretirana različitim nefrotoksičnim agensom: diklofenom, gentamicinom i folnom kiselinom i kontrolnu koja je tretirana fiziološkim rastvorom. Nakon eksperimentalnog tretmana i žrtvovanja sprovedena su ispitivanja na izolovanom srcu metodom po Langendorff-u praćenjem parametara srčane funkcije: dp/dt max, dp/dt min, SLVP, DLVP, HR i CF, dok su spektrofotometrijskim metodama u efluentu i plazmi određeni parametri oksidacionog stresa (TBARS, NO2-, O2-, H2O2) i u lizatu eritrocita parametri antioksidacione zaštite (CAT, SOD, GSH). ELISA metodom u plazmi određeni su biomarkeri inflamacije (TNF-α, IL-1, IL-6). Rezultati ove studije pokazuju da akutno oštećenje bubrega utiče na kardijalnu hemodinamiku, sistemska i kardijalna oksidacijska svojstva kao i na sistemsku inflamaciju i pomaže u rasvetljavanju efekata akutnog oštećenja bubrega na funkciju i redoks potencijal kardiovaskularnog sistema. The aim of this study was to examine the effect of acute kidney injury caused by nephrotoxic ages: gentamicin, diclofen and folic acid on myocardial function and the inflammatory-oxidative status of rats. The study included 100 ѕix week old male Wistar albino rats, with an average body weight about 200 grams. Rats were divided into three experimental groups, each of them were treated with a different nephrotoxic agent: diclofenac, gentamicin and folic acid, and a control group treated with saline. After experimental treatment and sacrifice, studies on the isolated heart were performed by the Langendorff method by monitoring the parameters of cardiac function: dp / dt max, dp / dt min, SLVP, DLVP, HR and CF. The parametres of oxidative stress (TBARS, NO2-, O2-, H2O2) in effluent and plasma were determined by spectrophotometric methods as well as parameters of antioxidant protection (CAT, SOD, GSH) in erythrocyte lysate. Biomarkers of inflammation in plasma (TNF-α, IL-1, IL-6) were determined by ELISA method. The results of this study show that acute renal impairment affects cardiac hemodynamics, systemic and cardiac oxidative properties as well as systemic inflammation and helps to elucidate the effects of acute renal impairment on the function and redox potential of cardiovascular system. - 91552100 76732169 91552101 8581 2022-10-20T14:15:46.053Z 45 no 46 Tomislav, 1980- Nikolić 25329255 2022 63 mentor Dejan, 1968- Petrović 13573991 2022 63 predsednik komisije Vladimir, 1984- Živković 12116071 2022 63 član komisije Miloš, 1987- Nikolić 20627559 2022 63 član komisije Jasna, 1975- Trbojević-Stanković 29760103 2022 89 listova 3668685 http://phaidrakg.kg.ac.rs/o:1537 no yes 10 2022-10-20T14:15:46.320Z 70 akutno oštećenje bubrega, izolovano srce pacova, kardiovaskularni sistem, oksidacioni stres, inflamacija acute kidney injury, isolated rat heart, cardiovascular system, oxidative stress, inflamation 599.323.4:616.61(043.3) 1738 34A05 2022