o:1606 Утицај квалитета метаболичке контроле на исход лечења физикалним процедурама болесника са гонартрозом и дијабетес мелитусом тип 2 The influence of the quality of metabolic control on the outcome of treatment with physical procedures of patients with gonarthrosis and type 2 diabetes melitus : doctoral dissertation sr UVOD: Gonartroza i DM tip 2 su dve bolesti koje sve češće koegzistiraju, što zbog velike prevalencije, što zbog brojnih zajedničkih faktora rizika. Primena fizikalne terapije zauzima značajno mesto u lečenju kako pacijenata sa gonartrozom, tako i pacijenata sa DMtip 2. Magnetoterapija i kineziterapija su agensi koji se najčešće koriste za lečenje pacijenata sa gonartrozom. CILj: Osnovni cilj ovog rada bio je da se ispita uticaj DM tip 2 na ishod lečenja fizikalnom terapijom pacijenata sa gonartrozom.METODE: Eksperimentalna studija kojom je obuhvaćeno 66 pacijenata, podeljeni u dve grupe u odnosu na prisustvo DM tip 2. Eksperimentalnu grupu su činili pacijenti sa gonartrozom i DM tip 2, a kontrolnu grupu pacijenti sa gonartrozom. Tokom analize podataka eksperimentalna grupa je podeljena na pacijente sa gonartrozom i regulisanim DM tip 2 i grupu sa gonartrozom i neregulisanim DM tip 2. Varijable praćene u istraživanju su biohemijski parametri, citokini (TNF-α, IL-6, IL-17, IL-10, INF-γ, IL-12, IL-23, TGF-β, IL-33, Gal-3)), WOMAC upitnik, Mc-Gill upitnik, VAS skala, EQ5D upitnik, Lequesne indeks, test monofilamenta, MNSI, NSS, NDS, MMT, merenje obima pokreta u zglobu. REZULTATI: Rezultati pokazuju da fizikalna terapija ima pozitivan efekat kod pacijenata sa gonartrozom i DM tip 2, kao i kod pacijenta sa gonartrozom, mereno kroz skor WOMAC indeksa. DM tip 2 ima negativan efekat na fizikalnu terapiju kod pacijenata sa gonartrozom.ZAKLjUČAK: Na osnovu dobijenih rezultata možemo zaključiti da loša glikoregulacija može imati negativan uticaj na ishod lečenja fizikalnom terpijom pacijenta sa gonartrozom. INTRODUCTION: Gonarthrosis and DM type 2 are two diseases that coexist more and more often, due to their high prevalence and due to numerous common risk factors. The application of physical therapy occupies an important place in the treatment of both patients with gonarthrosis and patients with DM type 2. Magnetotherapy and kinesitherapy are the agents most often used to treat patients with gonarthrosis.AIM: The main goal of this work was to examine the impact of DM type 2 on the outcome of physical therapy treatment of patients with gonarthrosis.METHODS: An experimental study that included 66 patients, divided into two groups in relation to the presence of DM type 2. The experimental group consisted of patients with gonarthrosis and DM type 2, and the control group consisted of patients with gonarthrosis. During data analysis, the experimental group was divided into patients with gonarthrosis and regulated DM type 2 and a group with gonarthrosis and unregulated DM type 2. The variables monitored in the study were biochemical parameters, cytokines (TNF-α, IL-6, IL-17, IL-10, INF-γ, IL-12, IL-23, TGF-β, IL-33, Gal-3)), WOMAC questionnaire, Mc-Gill questionnaire, VAS scale, EQ5D questionnaire, Lequesneindex, monofilament test, MNSI, NSS, NDS, MMT, wrist range of motion measurement.THE RESULTS: The results show that physical therapy has a positive effect in patients with gonarthrosis and DM type 2, as well as in patients with gonarthrosis, as measured by the WOMACindex score. DM type 2 has a negative effect on physical therapy in patients with gonarthrosis.CONSLUSION: Based on the obtained results, we can conclude that poor glycoregulation can have a negative impact on the outcome of physical therapy treatment of a patient with gonarthrosis - 91552100 121760265 91552101 8647 2023-07-31T10:04:33.053Z 45 no 46 Jelena, 1987- Milošević 65090825 2022 63 mentor Aleksandra, 1968- Jurišić-Škevin 25906023 2022 63 član komisije Igor, 1967- Simanić 53123593 2022 63 član komisije Aleksandar, 1956- Đukić 13561191 2022 63 član komisije Milica Lazović 17382247 2022 108 листова 2799326 http://phaidrakg.kg.ac.rs/o:1606 no yes 12 2023-07-31T10:04:33.320Z 70 Gonartroza, dijabetes melitus, WOMAC upitnik, fizikalna terapija, magnetoterapija, kineziterapija, citokini, polineuropatija Gonarthrosis, diabetes mellitus, WOMAC questionnaire, physical therapy, magnetotherapy, kinesitherapy, cytokines, quality of life, polyneuropathy 616.728.3:616-002.77-085(043.3)616.379(043.3) 1738 2022