
<ns0:uwmetadata xmlns:ns0="http://phaidra.univie.ac.at/XML/metadata/V1.0" xmlns:ns1="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0" xmlns:ns10="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0" xmlns:ns11="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0/entity" xmlns:ns12="http://phaidra.univie.ac.at/XML/metadata/digitalbook/V1.0" xmlns:ns13="http://phaidra.univie.ac.at/XML/metadata/etheses/V1.0" xmlns:ns2="http://phaidra.univie.ac.at/XML/metadata/extended/V1.0" xmlns:ns3="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/entity" xmlns:ns4="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/requirement" xmlns:ns5="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/educational" xmlns:ns6="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/annotation" xmlns:ns7="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/classification" xmlns:ns8="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/organization" xmlns:ns9="http://phaidra.univie.ac.at/XML/metadata/histkult/V1.0">
  <ns1:general>
    <ns1:identifier>o:264</ns1:identifier>
    <ns1:title language="sr">Značaj kvantifikacije markera onkogeneze u tkivnim isečcima obolelih od planocelularnog karcinoma larinksa i hroničnog laringitisa </ns1:title>
    <ns1:language>sr</ns1:language>
    <ns1:description language="sr">Progresija hroničnog laringitisa i nastanak karcinoma larinksa vezan je za aktivaciju različitih onkogena i inaktivaciju tumor supresorskih gena. Proteinski produkti ovih gena se imunohistohemijski detektuju u tkivnim isečcima obolelih pacijenata. Utvrđeno je da karcinomi larinksa sa istim kliničkim i histološkim osobenostima imaju različito biološko ponašanje, a samim tim i prognozu. Hronični laringitisi se karakterišu displazijom koja se može stepenovati u tri stadijuma i kod koje postoji takođe izmenjena ekspresija onkogena i antionkogena. Klinički i histološki nalaz dopunjeni imunohistohemijskim bojenjem tkivnih preparata pružaju dodatnu infomaciju neophodnu u tretiranju hroničnog laringitisa i karcinoma larinksa. Najčešće je izmenjena ekspresija onkogena cyclin D1 i FGF3 kod hroničnog laringitisa i karcinoma larinksa. Od tumor supresorskih gena veoma često su alterisani p16 i p21.</ns1:description>
    <ns1:description language="en">Progression of chronic laryngitis and laryngeal cancer development are related to the activation of various oncogenes and inactivation of tumor suppressor genes. Protein products of these genes are detected by immunohistochemistry in tissue slices in ill patients. It has been deterimined that laryngeal cancers with the same clinical and histological characteristics have different biological behaviour, and therefore, different prognosis. Chronic laryngitis is characterized by dysplasia, which can be graded into three stages, with altered oncogenes and anti-oncogenes expression. Clinical and histological findings, complemented by immunohistochemical staining of tissue preparations, provide additional information necessary in the treatment of chronic laryngitis and laryngeal cancer. The expression of oncogene cyclin D1 and FGF3 are most often changed in chronic laryngitis and laryngeal cancer. Tumor suppressor genes that are often altered are p16 and p21 .</ns1:description>
    <ns1:description language="sr">datum odbrane:27.12.2013.</ns1:description>
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        <ns3:firstname> Stevan P.</ns3:firstname>
        <ns3:lastname>Stojanović</ns3:lastname>
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        <ns3:firstname> Branislav</ns3:firstname>
        <ns3:lastname>Belić</ns3:lastname>
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        <ns3:firstname> Ljubica</ns3:firstname>
        <ns3:lastname>Živić</ns3:lastname>
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        <ns3:firstname> Nebojša </ns3:firstname>
        <ns3:lastname>Arsenijević</ns3:lastname>
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        <ns3:firstname> Milan</ns3:firstname>
        <ns3:lastname>Knežević</ns3:lastname>
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      <ns1:date>2013</ns1:date>
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      <ns6:date>2014-00-25T11:11:58.320Z</ns6:date>
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    <ns1:purpose>70</ns1:purpose>
    <ns7:keyword language="sr" seq="1">larinks, karcinom, hronični laringitis, cyclin D1, FGF3, p16, p21</ns7:keyword>
    <ns7:keyword language="sr" seq="1">hronični laringitis</ns7:keyword>
    <ns7:keyword language="sr" seq="1">cyclin D1</ns7:keyword>
    <ns7:keyword language="sr" seq="1">FGF3</ns7:keyword>
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