
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title xml:lang="srp">Transport LDL-a u u izolovanoj karotidi kunića pre i tokom razvoja ateroskleroz</dc:title>
  <dc:creator>Milošević,  Maja, 1983-</dc:creator>
  <dc:description xml:lang="eng">The study included 20 New Zealand White rabbits with surgically isolated segments of left and right common carotid artery. The animals were divided into four groups: control group- normal feeding and three experimental groups with 1% cholesterol added to normal feeding (atherogenic diet) during 8, 10 and 12 weeks. The isolated segment of rabbit carotid artery was used under constant perfusion flow and pressure-induced (0 mmHg and 140 mmHg) blood vessel distension, with the possibility to change and precisely calculate shear stress during the experiment. In order to examine 125I-LDL  ransport the continual 10-min perfusion was used (100 μl/min) (Steady state method). The measured 125I-LDL specific activity in each sample was used to obtain radioactivity-time curves, that is, dilution profiles for 125I-LDL during its flow through the blood vessel at a set value of perfusion pressure. The evaluation of 125I LDL transport into isolated blood vessel wall was calculated as difference between inflow and outflow dose of 125I-LDL-within the period of Steady state.
 Obtained results are showed and well documented with 3 tables, 8 figures and 2
mathematical equations. The results showed increased LDL transport after removal of endothelium and the pressure-induced (0 mmHg and 140 mmHg) blood vessel distension has its influence at LDL transport. It was showed that in conditions of prolonged hyperlipidaemia (atherogenic diet) with low pressure-induced blood vessel distension (0 mmHg) LDL transport into blood vessel wall is ,decreased as well as values of shear stress. However, with high pressure-induced blood vessel distension (140 mmHg) LDL transport into blood vessel wall is increased although values of shear stress increase
too.</dc:description>
  <dc:description xml:lang="srp"></dc:description>
  <dc:contributor>Rosić,  Mirko, 1958-</dc:contributor>
  <dc:contributor>Pantović,  Suzana, 1959-</dc:contributor>
  <dc:contributor>Rosić,  Gvozden, 1964-</dc:contributor>
  <dc:contributor>Đurić,  Dragan, 1961-</dc:contributor>
  <dc:date>2016</dc:date>
  <dc:date>2016</dc:date>
  <dc:date>2016</dc:date>
  <dc:date>2016</dc:date>
  <dc:date>2016</dc:date>
  <dc:date>2016</dc:date>
  <dc:type xml:lang="eng">baccalaureate Dissertation</dc:type>
  <dc:format>152 lista</dc:format>
  <dc:format>3943379 bytes</dc:format>
  <dc:identifier>o:596</dc:identifier>
  <dc:identifier>ID=522587797 ; D=2901</dc:identifier>
  <dc:identifier>thesis:2444</dc:identifier>
  <dc:identifier>cobiss:522587797</dc:identifier>
  <dc:identifier>https://phaidrakg.kg.ac.rs/o:596</dc:identifier>
  <dc:source>Thesis:2444</dc:source>
  <dc:source>Cobiss:522587797</dc:source>
  <dc:language>srp</dc:language>
  <dc:rights>CC BY-NC-SA 2.0 AT</dc:rights>
  <dc:rights>http://creativecommons.org/licenses/by-nc-sa/2.0/at/</dc:rights>
</oai_dc:dc>